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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Zu-Cheng Ye

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Aug 2026

EAAT1 sustains redox homeostasis and temozolomide resistance through glutamate-dependent regulation of the Keap1/Nrf2 axis in glioblastoma.

Glioblastoma (GBM) exhibits profound metabolic and redox adaptation that supports tumor progression and therapeutic resistance. Here, we identify the glutamate transporter EAAT1 (SLC1A3) as a critical regulator of glutamate-dependent redox homeostasis in GBM. Analysis of TCGA and CGGA datasets showed that EAAT1 express...

Lu-Fei Chen, Ru-Ying Lin, Yong-Pei Xu et al. · 0 citations
Open access Sep 2026

Sleep Deprivation Induces Glial Dysfunction, Synaptic Loss, Metabolic Imbalance, and Cognitive Impairment in 12‐Month‐Old Mice: Protective Effects of D30

ABSTRACT Background Sleep deprivation (SD) has been increasingly implicated in age‐related cognitive decline. However, the mechanisms linking SD duration to progressive disruption of glial homeostasis, synaptic vulnerability, and metabolic dysregulation remain poorly defined. Methods We employed 12‐month‐old Thy1‐EGFP...

Xue-Yan Liu, Hui-Ling Lin, Jian Zhong et al. · 0 citations

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