Peptide stapling exerts profound effects on key peptide properties, including metabolic stability, cell membrane permeability, and conformational constraint. Herein, we report a mild and efficient 2,4-dichloro-1,3,5-triazine-mediated stapling strategy for the selective cross-linking of lysine side-chain amines. This ap...
A computational, structure-, dynamics-, and energetics-resolved framework for cyclic peptide recognition at the PP2A-B55α regulatory groove is established and testable hypotheses for experimental validation are defined.
Muhammad Waqas, Li Xuan, Haoke Zhang et al.· International Journal of Bio...· 0 citations
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