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Author

Zunnan Huang

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Aug 2026

Triazine Linchpins for Selective Lys-Lys Stapling of Unprotected Peptides.

Peptide stapling exerts profound effects on key peptide properties, including metabolic stability, cell membrane permeability, and conformational constraint. Herein, we report a mild and efficient 2,4-dichloro-1,3,5-triazine-mediated stapling strategy for the selective cross-linking of lysine side-chain amines. This ap...

Peiru Chen, Anhui Mao, Jingxiu Xu et al. · 0 citations
Jul 2026

Mechanistic insights into macromolecular recognition at the PP2A-B55α regulatory groove from structure-based modeling and molecular dynamics.

A computational, structure-, dynamics-, and energetics-resolved framework for cyclic peptide recognition at the PP2A-B55α regulatory groove is established and testable hypotheses for experimental validation are defined.

Muhammad Waqas, Li Xuan, Haoke Zhang et al. · 0 citations

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