DrugReason is proposed, a multi-view reasoning framework that integrates grounded KG reasoning with LLM-generated mechanistic inference for drug repurposing and achieves competitive or superior results compared with graph-based alternatives, while providing interpretable routing-based predictions.
Zi-Jie Liu, Hong-Xuan Li, Zhen Tan et al.· 0 citations
Deciphering the regulatory consequences of sequence divergence across human evolution is essential to understanding the molecular basis of human-specific traits and disease. Although millions of derived alleles distinguish humans from great apes, only a small fraction are likely to influence human-specific traits. Prev...
Riley J. Mangan, Nikitha Thoduguli, Dimitar Ivanov et al.· bioRxiv· 0 citations
Phenoverse is introduced, an interpretable deep learning framework that learns sample-level disease state representations through cell type-aware residual encoding, prototype learning, and Perceiver-based aggregation that demonstrates that trajectory-derived genes reveal cross-cohort molecular programs and show consist...
Manoj M Wagle, Yongheng Wang, Soham Samanta et al.· bioRxiv· 0 citations
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