Zuo-Ao Shi

Sodium valproate at concentrations bracketing estimated seminal plasma levels impairs human sperm function in vitro through oxidative stress and mitochondrial dysfunction.

Sodium valproate (VPA), a first-line broad-spectrum antiseizure medication, has been associated with altered semen quality in clinical settings, but its direct effects on human sperm remain incompletely defined. In this in vitro study, sperm from normozoospermic donors were exposed to VPA concentrations bracketing an e...