Dynamic covalent/coordinated nanonetworks with DNase-mimetic and ROS scavenging properties for acute inflammation treatment.
Sterile inflammation driven by cell-free DNA (cfDNA) and reactive oxygen species (ROS) underlies acute inflammatory disorders, yet current therapies fail to specifically target these upstream mediators. We report a dynamic covalent/coordinated nanonetwork (DC2 NNW) that combines drug delivery, DNase-mimetic and ROS-sca...