Large language model (LLM) agents excel at complex, multi-step tasks but suffer from catastrophic forgetting during continual learning--acquiring new skills often degrades previously mastered capabilities. Existing post-training paradigms face a fundamental trade-off: Supervised Fine-Tuning (SFT) is sample-efficient bu...
Yu-Qian Fu, Kai-Wen Jiang, Zi-Jun Song et al.· 0 citations
Imitation learning typically treats every demonstration state as equally important, optimizing a behavior-cloning objective uniformly across the dataset. Yet not all states are created equal: in a small number of critical states, even a slight deviation from the expert action can lead to a failure, while in many other...
Yusuf Umut Ciftci, Joonwon Kang, Ajay Suresha Sathya et al.· 0 citations
AI systems now write long and difficult mathematical proofs, and checking their step-by-step validity is becoming a bottleneck. A learned verifier could check proofs cheaply, but training one requires a correctness label on every step, and such labels are hard to obtain for open-ended proofs. Existing methods take them...
Rodney Lafuente-Mercado, Salman Rahman, Jing-Yan Shen et al.· 0 citations
Identifying protein-ligand binding sites (pockets) is important for understanding protein function and developing drugs. However, no public method has leveraged co-folding models for novel pocket prediction; furthermore, this task lacks a suitable benchmark as existing benchmarks are within the training distribution of...
Tally Portnoi, Allison M. Keys, B. DiFrancesco et al.· 0 citations
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Enterprise agents face safety risks that cannot be determined from individual actions alone. Existing safety benchmarks largely evaluate action-local risks, overlooking failures whose safety depends on workflow state. In such state-dependent risks, the same action may be safe in one context but violate policy in anothe...
Jingyue Cong, Estrid He, Zhuang Li et al.· 0 citations
Chain-of-thought (CoT) improves reasoning but incurs substantial autoregressive rationale cost. Continuous CoT moves intermediate computation into recurrent hidden states, yet typically uses a fixed number of updates even though the best budget varies across questions and accuracy need not improve monotonically with $K...
Ying Li, Yu-Qian Chen, Sixuan Li et al.· 0 citations
Reinforcement learning with verifiable rewards (RLVR) for multi-turn agents relies on sparse terminal rewards that say little about individual steps. Within-group step comparisons depend on reliable state matching and sufficiently diverse sampled outcomes, while direct step scoring may require costly external evaluator...
Xu-Yan Ye, Xiyan Fu, Sheng-Da Fan et al.· 0 citations
The Safety-Aware Denoiser (SAD) is a recent, training-free, safety-guidance framework for text diffusion models. During inference, SAD steers text samples toward safe regions of the token probability space. In this paper, we propose $\mathit{SADDER}$ (Safety-Aware Denoising with Directional Embedding-based Revision), w...
Amman Yusuf, Jiwoo Shin, Ruizhi Deng et al.· 0 citations
Rubric-based reinforcement learning grades a response against many written criteria but collapses them into one reward, which discards the detail the rubric carries and gives no GRPO reward gradient when a group's responses tie. A frozen teacher that reads the rubric as privileged context provides token-level supervisi...
Kunwang Zheng, Xinyu Sun, Yu Cao et al.· 0 citations
Background: Five-year survival prediction from hematoxylin-and-eosin whole-slide images could support risk stratification, but the task is weakly supervised, and the tissue morphologies carrying prognostic information remain incompletely characterized. Methods: We conducted a retrospective secondary analysis using TCGA...
Hikmat Khan, M. Gurcan, Anil Parwani et al.· 0 citations
Diffusion language models (DLMs) have attracted wide attention for their fast, parallel decoding, but they are believed to be far less efficient to train than autoregressive language models (ARMs): a widely cited study reports that a DLM needs roughly 16x the training compute of an ARM to match its likelihood, a figure...
Guang-Han Wang, B. He, Zhan Shi et al.· 0 citations
Muon controls weight updates through the RMS movement of a linear layer's output. This implicitly treats the linear output as a proxy for the full module, including the nonlinearity that follows. This proxy can be misleading for softmax, where the RMS shift in activations does not faithfully measure the change in the o...
Aditya Somasundaram, Charles Guille-Escuret, Alexander Moreno et al.· 0 citations
A machine-learning approach called CheMeleon provides a practical way to develop new drugs or other molecules with much less detailed, expensive experimentation.
Research Manager Mike Walker reflects on a career spanning hacker culture, cybersecurity, and AI, sharing lessons about trust, teamwork, leadership, and why solving difficult problems requires curiosity, judgment, agility—and an understanding of the rules. The post Learn the rules: The hacker mindset appeared first on Microsoft Research.
Learn how Google Antigravity and our Cheminformatics Skills accelerate drug discovery workflows, search compounds, and propose novel rigidified macrocycles.
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