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18,068 papers
Fine-tuning large language models at scale is increasingly limited by the memory cost of backpropagation. Zeroth-Order (ZO) optimizers reduce this burden by relying only on forward function evaluations, but they still exhibit a substantial performance gap to first-order (FO) optimizers such as Adam. We argue that this...
This work proposes ChainSleuth, a graph-tool-augmented agent that iteratively reasons, invokes graph tools, and updates its tracing trajectory, enabling adaptive information acquisition and recovery from erroneous paths in multi-hop fund tracing.
Medication recommendation requires jointly considering diagnoses, comorbidities, longitudinal patient history, and treatment interactions. Although recent retrieval-augmented generation approaches using language models have shown promise for clinical recommendation, most existing systems rely on fixed retrieval pipelin...
Looped Language Models (LoopLMs) improve parameter efficiency by recursively reusing shared Transformer modules, yet their repeated computation over evolving recurrent states poses new challenges for low-bit deployment. Existing post-training quantization (PTQ) methods, largely designed for feed-forward Transformers, f...
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During adolescence, significant changes in brain development are influenced by hormonal changes that impact both the body and the brain. This study presents sex classification in 787 young adults having age range of 15-25 years using Diffusion-weighted (DWI) structural connectome, focusing on 82 Desikan-Killiany atlas...
Forward-Forward learning replaces end-to-end backpropagation with local, layer-wise training objectives. Its variants are evaluated primarily by classification accuracy, often measured with linear probes trained on their representations. We show that this evaluation can over-credit the learning method: a linear probe o...
Discovering behavioral patterns in open-ended games is challenging due to the lack of clear objectives or ground-truth annotations. In this work, we extend a next-token prediction Transformer with the deep clustering algorithm DCSS to learn meaningful representations with well-separated clusters. In a controlled Minecr...
SLDBench v2 is introduced with two extensions, and active scaling law discovery is introduced: an agent chooses which experiments to run, pays each one's recorded cost, and revises its law as outcomes arrive, and is scored on the same hidden extrapolation targets as in the passive setting.
Flow Matching (FM) has recently emerged as a principled and efficient generative modeling framework for reinforcement learning (RL), enabling expressive, multimodal policy parameterizations via deterministic probability transport. Compared to diffusion-based policies that rely on stochastic denoising chains, FM uses sa...
We study sampling from $\pi(x)\propto\mathrm{e}^{-V(x)}$ on $\mathbb{R}^d$, where $V$ is $\alpha$-strongly convex and $\beta$-smooth with condition number $\kappa=\beta/\alpha$. For this problem, the proximal sampler preserves the target exactly and recovers overdamped Langevin dynamics in the small-step limit, but its...
In-silico optimization of nucleic acids relies on predictive oracles that imperfectly capture biological function, so sequences optimized against one model may exploit model-specific artifacts and fail to generalize to independent models. Recent studies have shown that not all designers generalize equally well to indep...
Spatial transcriptomics jointly captures molecular state, tissue morphology, and spatial organization, yet spatial-domain methods are typically compared only at late training checkpoints, obscuring differences in convergence efficiency. We introduce MP-MNCA, a morphology-prior masked neighbor cross-attention framework...
The new approach, known as FLEX, could lead to more intuitive, interactive household and assistive robots.
By learning how matter moves, the WorldParticle system could assist with developing soft robots, medicines, and more.
A machine-learning approach called CheMeleon provides a practical way to develop new drugs or other molecules with much less detailed, expensive experimentation.
A Blog post by Ai2 on Hugging Face
Research Manager Mike Walker reflects on a career spanning hacker culture, cybersecurity, and AI, sharing lessons about trust, teamwork, leadership, and why solving difficult problems requires curiosity, judgment, agility—and an understanding of the rules. The post Learn the rules: The hacker mindset appeared first on Microsoft Research.
Learn how Google Antigravity and our Cheminformatics Skills accelerate drug discovery workflows, search compounds, and propose novel rigidified macrocycles.
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