An integrated computational workflow that combines enhanced sampling techniques and machine learning collective variables to identify druggable conformations of the AR-NTD and elucidate the binding mechanism of its modulator, EPI-002 is introduced.
Kai Zhu, Huating Wang, Jin-Tu Zhang et al.· Nature Communications· 0 citations
Backtests covering 2014-2024 across seven equity indices show that the model achieves higher Sharpe ratios than the baselines while maintaining near-zero benchmark correlations and competitive drawdowns.
This paper investigates the application of a self-adaptive quantum simulation optimization algorithm to enhance the accuracy and efficiency of quantum simulations. Traditional simulation methods often rely on fixed parameters, limiting the potential for optimization. This research proposes a novel algorithm that dynami...
Jincheng Zhang· Zenodo (CERN European Organi...· 0 citations
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This paper explores the application of geometric constraints within reinforcement learning to enhance policy stability and effectiveness. Traditional reinforcement learning methods often struggle with complex environments where geometric considerations are crucial. We propose a novel geometric constraint formulation th...
Jincheng Zhang· Zenodo (CERN European Organi...· 0 citations
This paper introduces the Dynamic Semantic Embedding Network (DSE-Net), a novel approach to understanding evolving data streams. The core claim is that by integrating semantic embeddings with dynamic graph neural networks, we can achieve continuous, context-aware understanding, overcoming the limitations of static embe...
Jincheng Zhang· Zenodo (CERN European Organi...· 0 citations
This paper presents a novel approach to intelligent robot control by leveraging the fusion of multiple modalities – visual, tactile, and auditory – of information. The core idea is to enhance robot adaptability and intelligence in complex environments through sophisticated multi-modal data processing and intelligent co...
Jincheng Zhang· Zenodo (CERN European Organi...· 0 citations
This paper presents the Adaptive Error Correction for Complex Parameter Space (AECPS) algorithm, a novel approach to parameter estimation designed for complex parameter spaces. Traditional parameter estimation methods frequently struggle to adapt to dynamic changes in the parameter space, leading to suboptimal performa...
Jincheng Zhang· Zenodo (CERN European Organi...· 0 citations
This paper presents a novel dynamic topology optimization network routing algorithm designed to enhance network performance and resilience. The core concept involves real-time adaptation of the network topology based on dynamic network conditions such as congestion, latency, and node failures. This is achieved through...
Jincheng Zhang· Zenodo (CERN European Organi...· 0 citations
This paper presents a novel approach to neural network architecture search (NAS) leveraging meta-learning and Bayesian optimization. Traditional NAS methods often suffer from high computational costs associated with exhaustive or reinforcement learning-based exploration of the architecture search space. Our method, Bay...
Jincheng Zhang· Zenodo (CERN European Organi...· 0 citations
This paper introduces Dynamic Topological Semantic Learning (DTSL), a novel approach to semantic understanding based on interactive observation and dynamic topological graph construction. The core claim of DTSL is that a system can automatically learn and build semantic relationships between objects by observing and si...
Jincheng Zhang· Zenodo (CERN European Organi...· 0 citations
This paper investigates the application of collective emergence theory to multi-agent reinforcement learning (MARL). The core claim is that leveraging principles of collective emergence – specifically localized rules and nonlinear interactions – can guide multi-agent systems to spontaneously generate novel behaviors an...
Jincheng Zhang· Zenodo (CERN European Organi...· 0 citations
Research Manager Mike Walker reflects on a career spanning hacker culture, cybersecurity, and AI, sharing lessons about trust, teamwork, leadership, and why solving difficult problems requires curiosity, judgment, agility—and an understanding of the rules. The post Learn the rules: The hacker mindset appeared first on Microsoft Research.
Learn how Google Antigravity and our Cheminformatics Skills accelerate drug discovery workflows, search compounds, and propose novel rigidified macrocycles.
MIT News · Artificial Intelligence· news.mit.eduOct 27, 2026
Prabha Jha used her experience with MIT Open Learning’s program for senior executives to develop AI solutions for her employer, Verizon, and to write a book.
Assistant Professor Benjamin Lindquist studies how engineers deliberately injected randomness into early AI, giving rise to deep-learning models that sometimes hallucinate.
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