Cancer-associated fibroblasts-derived CAV1 promotes epithelial-mesenchymal transition and stemness in bladder cancer through activation of the LIF/STAT3 signaling pathway

Sep 2026

Cancer-associated fibroblast-enriched TAGLN orchestrates HGF/c-MET-dependent transcriptional reprogramming in gastric cancer.

A CAF-TAGLN/HGF/c-MET/DDX5/CAV1 signaling cascade linking stromal activation to tumor-cell transcriptional reprogramming and CAF-tumor crosstalk within the TME is defined to identify TAGLN as a potential therapeutic vulnerability for microenvironment-directed intervention in GC.

Qiang Li, Jia-Ning Yang, Lu-Hong Cao et al. · Cancer Letters · 0 citations

Save

Copy APA Copied ✓ Copy MLA Copied ✓ Copy BibTeX Copied ✓

Aug 2026

Cancer-associated fibroblast-derived vascular endothelial growth factor a promotes gastric cancer organoid growth and chemotherapy resistance via paracrine signaling.

A VEGFA-associated functional CAF state promotes gastric cancer organoid growth and chemoresistance through paracrine signaling, highlighting the CAF-VEGFA axis as a potential therapeutic target.

Hongmei Fan, Ling Wang, Chuan-Zhong Huang et al. · Cellular Signalling · 0 citations

Save

Copy APA Copied ✓ Copy MLA Copied ✓ Copy BibTeX Copied ✓

Sep 2026

Mechanism of cancer-associated fibroblasts-derived exosomes-shuttled snail regulating the SOCS6/HIF-1α axis to promote pancreatic cancer stemness and gemcitabine resistance.

OBJECTIVE Cancer-associated fibroblasts (CAFs) contribute to pancreatic cancer (PC) progression and therapeutic resistance. This study investigated whether CAF-derived exosomes (CAF-exo)-promote PC cell stemness and gemcitabine (GEM) resistance by delivering Snail and regulating the suppressor of cytokine signaling 6/h...

Zhen Luo, Yuqin Hu, Jian Li et al. · Cellular Signalling · 0 citations

Save

Copy APA Copied ✓ Copy MLA Copied ✓ Copy BibTeX Copied ✓

Open access Sep 2026

GLG1 in cancer-associated fibroblasts promotes bladder cancer growth while limiting tumor apoptosis

Cancer-associated fibroblasts (CAFs) shape bladder cancer progression, but functionally relevant CAF-associated drivers remain insufficiently characterized. This study aimed to identify CAF-enriched genes with translational relevance and to determine whether GLG1 mediates tumor–stromal crosstalk in bladder cancer. Sing...

Jing-Peng Liu, Zhong-Bao Zhou, Bai-Ning Zhang et al. · Apoptosis · 1 citation

Save

Copy APA Copied ✓ Copy MLA Copied ✓ Copy BibTeX Copied ✓

Open access Aug 2026

Stage-dependent upregulation of tumor-derived MDK is associated with CAF state remodeling and an ECM-rich immunosuppressive microenvironment in colorectal cancer

The data support a progression-linked association among tumor-cell-enriched MDK, CAF state remodeling, an ECM-high Fib-WNT5A program, and predicted collagen-mediated immune interactions in CRC.

Xia Liu, Siyuan Ma, Shuai Wu et al. · BMC Cancer · 0 citations

Save

Copy APA Copied ✓ Copy MLA Copied ✓ Copy BibTeX Copied ✓

Open access Aug 2026

Cancer‐Associated Fibroblasts Promote Glucose Metabolic Reprogramming and Progression of Triple‐Negative Breast Cancer via Exosomal circFAD104‐Mediated Intercellular Communication

These findings uncover a CAF‐exosomal circFAD104 axis that reprograms glucose metabolism to drive TNBC progression via the circFAD104/MARCHF8/PGM1 pathway, highlighting its potential as a stroma‐targeted biomarker and prognostic predictor.

Lei Wang, Xiaoyan Li, Yi-Ran Liang et al. · Advancement of science · 0 citations

Save

Copy APA Copied ✓ Copy MLA Copied ✓ Copy BibTeX Copied ✓