In vitro release tests demonstrated that MSn with a good biocompatibility could effectively enhance the dissolution rate of FNB and Pharmacokinetic results indicated that MSn significantly increased the oral relative bioavailability of FNB.
Porous silicates have been investigated as drug carriers to promote the solubility and in vitro dissolution of poorly water-soluble drugs, owing to their potential to adsorb drug molecules in the amorphous form within their structural cavities. This study aimed to evaluate the efficiency of bentonite (BT), Aeroperl 300...
Gaurav Dhumal, Adélaïde Savoy, M. Kuentz et al.· International journal of pha...· 0 citations
Oxiconazole nitrate-loaded nanospheres were successfully developed using the emulsification–solvent evaporation method to enhance the solubility and dissolution of oxiconazole nitrate, a Biopharmaceutics Classification System (BCS) Class II antifungal drug characterized by low aqueous solubility and good membrane perme...
Suyash Shashikant Ingle, A. Chavan, Vasundhara Somnath Patil et al.· International Journal of Sci...· 0 citations
Mefenamic acid is a Non Steroidal anti- inflammatory drug belonging to the BCS class II. It has a low oral bioavailability due to poor aqueous solubility and poor dissolution rate. The present study was undertaken to improve the dissolution, absorption, and bioavailability of Mefenamic acid by employing spherical agg...
P. Rambabu, P. Shailaja· Adolescência e Saúde· 0 citations
Poor aqueous solubility remains the single most common cause of variable and incomplete oral absorption among new chemical entities, with a substantial proportion of marketed and pipeline molecules falling under Biopharmaceutics Classification System (BCS) classes II and IV. Self-nanoemulsifying drug delivery systems (...
Deepa Cherian and Dr. Rakesh Kumar Jat· International Journal of Adv...· 0 citations
The aqueous solubility and membrane permeability of Biopharmaceutics Classification System (BCS) class II and IV drugs, such as furosemide (FUR), sulfadiazine (SDZ), verapamil (VEP), mefloquine (MEF), and the bioactive compound quercetin (QUE), are low. Thus, affecting the oral bioavailability of these drugs. In our st...
Felipe Guizze, S. Sueyoshi, Helena Castilho et al.· International journal of pha...· 0 citations
Atorvastatin calcium, a widely prescribed HMG-CoA reductase inhibitor used in the management of hypercholesterolemia and dyslipidaemia, belongs to BCS Class II, characterized by low aqueous solubility and consequently poor and variable oral bioavailability (approximately 12–14%). This limitation arises primarily from p...
R. Gandhi, V. Gunaseelan, M. Prakash et al.· IJPAR JOURNAL· 0 citations
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