Sensory impairment and accelerated GrimAgeAccel jointly identified older adults at elevated risk of subsequent functional decline and mortality, which support a risk-stratification framework integrating clinically accessible sensory assessment with DNAm-based biological ageing measures.
Sensory impairment, particularly dual sensory impairment, was most consistently associated with early cognitive deterioration and reduced cognitive recovery, and was not consistently associated with higher dementia progression or mortality transition rates.
BACKGROUND
Cardiovascular health (CVH) is associated with individual age-related health outcomes, but its relation to unhealthy aging trajectories remains uncertain. We assessed whether CVH is associated with the baseline burden of unhealthy aging and its progression over time, and whether these associations differ by...
D. Gómez-Ángel, M. Sotos-Prieto, E. García-Esquinas et al.· GeroScience· 0 citations
Higher epigenetic clock biological age estimates, particularly DNAmGrimAge, are retrospectively associated with accelerated frailty-related functional decline across multiple functional domains.
Savvina Prapiadou, T. Kimball, B. Tan et al.· The journals of gerontology....· 0 citations
Preserved cognitive performance in late life, based primarily on persistent MMSE performance, is associated with a decelerated biological aging profile in community-dwelling older adults, consistent with the hypothesis that DNA methylation-derived epigenetic markers may help characterize healthy cognitive aging traject...
F. Salech, C. Márquez, P. Correa-Burrows et al.· Aging and Disease· 0 citations
Aging is a heterogeneous process characterized by marked variability in biological, cognitive, and functional trajectories among individuals of the same chronological age. Consequently, there is greater interest in biomarkers capable of identifying early deviations from healthy aging and predicting adverse outcomes. Th...
A. Mimenza-Alvarado, S. Aguilar-Navarro, M. E. Hernandez et al.· Revista de investigacion cli...· 0 citations
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