A Review on Computational Design of 3- Heteroaryl Coumarin Derivatives as Dual Site Acetylcholinesterase Inhibitors for Alzheimer's Disease

Abstract

Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder primarily treated by augmenting cholinergic neurotransmission. Traditional acetylcholinesterase inhibitors (AChEIs) offer modest symptomatic relief but often lack disease-modifying capabilities.