To Know the Association Between IRISIN and Spirometry, 6 Minute Walk Test, Clinical Features, Dyspnea Score and Quality of Life
TL;DR
Serum IRISIN levels are significantly high in COPD patients with pulmonary rehabilitation compared to COPD patients without pulmonary rehabilitation as hypothesized, suggesting IRISIN may also reflect changes in domains other than airflow limitation in COPD patients.
Abstract
Introduction: Chronic obstructive pulmonary disease (COPD) is one of the most common causes of disease burden both globally and in India it needs more emphasis than ever, the third leading cause of death in India and globally. There is a need for more diagnostic and therapeutic options. We studied Serum IRISIN in hope of finding a new biomarker for COPD. Serum IRISIN is a skeletal muscle protein associated with physical activity, the levels of which are increased in COPD patients after 8 weeks of pulmonary rehabilitation. There is no Indian data available on IRISIN in COPD patients. Objective: Primary objective of our study is to assess the level of serum IRISIN level in COPD before starting Pulmonary Rehabilitation and after 8 weeks of Pulmonary Rehabilitation. Secondary objective is to study correlation between IRISIN and spirometry, 6 minute walk test, Clinical features, Dyspnea score and Quality of life. Methodology: Cases were selected from OPD department of Pulmonary Medicine JSS Hospital Mysore. 80 subjects satisfying inclusion and exclusion criteria underwent PFT, 6MWT, SGRQ-C, CAT score, BODE index and ELISA for serum IRISIN levels. Statistical analysis included, Chi2 test/Fisher extract test, One, Independent t Test, Mann Whitney test, Pearson correlation test and spearman correlation test. Results: The mean age of the study group was 62.4 ± 9.8. Male subjects in the study were 50 and female subjects were 30. There is a significant increase in IRISIN levels between COPD (control group, no pulmonary rehabilitation) and COPD (intervention group, with pulmonary rehabilitation) with significant p value <0.001. Conclusion: IRISIN levels are significantly high in COPD patients with pulmonary rehabilitation compared to COPD patients without pulmonary rehabilitation as hypothesized. (p value <0.001). Serum IRISIN levels correlate well with quality of life suggesting IRISIN may also reflect changes in domains other than airflow limitation in COPD patients. There is no significant difference in serum IRISIN levels among male and female COPD patients, suggesting that levels of IRISIN are independent of age