Preoperative Hounsfield Unit Values, Cage Placement Position, and Cage Subsidence after Oblique Lumbar Interbody Fusion: A Retrospective Cohort Study

Abstract

Purpose: This study aimed to evaluate the predictive performance of preoperative computed tomography–based Hounsfield unit (HU) and magnetic resonance imaging-based vertebral bone quality score (VBQS) for cage subsidence after 1-to 2-level oblique lumbar inter-body fusion (OLIF), and whether it differs by intraoperative cage placement position. Methods: Ninety-one OLIF levels in 54 patients (2015–2022) were retrospectively reviewed in this single-center cohort. Subsidence was defined as ≥2 mm middle disc-height reduction or ≥2 mm cage protrusion at 1 year. Multivariable logistic regression with cluster-robust standard errors estimated adjusted odds ratios (OR); the pre-specified primary test was the lower-instrumented-vertebra HU×cage-posi-tion interaction. Results: Subsidence occurred in 24 of 91 levels (26.4%). Each one-standard-deviation decrease in lower-instrumented-vertebra HU was independently associated with subsidence (adjusted OR, 0.40; 95% confidence interval, 0.20 to 0.81; p=0.011); VBQS was not. The subsidence group included more osteoporosis-range levels (<110 HU; 62.5% vs. 25.4%, p=0.003). The interaction was not significant (p=0.553), but the HU effect concentrated in middle-placed cages (adjusted OR, 0.345; p=0.012) and attenuated in anterior-placed cages (OR, 0.50; p=0.185). Conclusion: Lower-instrumented-vertebra HU is an independent predictor of cage subsidence after 1-to 2-level OLIF, most evident in middle-placed cages.