Sep 2026· Diabetes, obesity and metabolism· Vol 28, pp. 11132 - 11142· 0 citations· 39 references
Medicine
TL;DR
Extreme AAO-defined T2D subtypes exhibit partially distinct genetic architectures, highlighting AAO as an important dimension of T2D heterogeneity and providing a framework for future age-stratified genetic risk assessment.
Abstract
Type 2 diabetes (T2D) is a heterogeneous disorder with substantial variation in age at onset (AAO). This study aimed to characterize the distinct genetic architectures and biological mechanisms underlying extreme AAO‐defined T2D subtypes.
BACKGROUND
Type 1 diabetes (T1D) is a common disease. Although genome-wide association studies (GWASs) have identified hundreds of associated single nucleotide polymorphisms (SNPs), very few T1D GWAS have simultaneously addressed both Asian and European populations.
METHODS
Here, we conducted a large-scale trans-ance...
Type 2 diabetes (T2D) is a highly heterogeneous metabolic trait, with a higher prevalence in East Asians. Despite extensive genetic studies focusing mainly on Europeans, how genetic risk for T2D is distributed across biological pathways in East Asians in comparison with Europeans remains incompletely understood. Here,...
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J. Thomassen, H. Leonard, Brittany Ulms et al.· Nature Genetics· 0 citations
An integrated cross-omics analysis identifies novel genetic loci and, crucially, uncovers specific nutrient-related metabolic pathways that mediate genetic risk in Aortic aneurysm and its subtypes.
Han-Xi Wang, Junjie Cheng, Jia-Li Yao et al.· Frontiers in Nutrition· 0 citations
The findings demonstrate that integrating tissue-specific and ancestry-aware TWAS refines the identification of causal genes for T2D, with cross-ancestry replication supporting the robustness of these signals and cross-tissue analyses revealing context-specific effects.
I. Pagnuco, S. Eyre, M. Rattray et al.· medRxiv· 0 citations
Background: Moderate-to-severe asthma affects 15-30% of asthma patients, but accounts for over 50% of healthcare costs and disproportionate morbidity. However, the genetic mechanisms underlying moderate-to-severe versus mild asthma remain poorly understood. Methods: We performed separate pooled multi-ancestry GWAS of m...
A. Mendy, Yadu Gautam, Birch Rosen et al.· medRxiv· 0 citations
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