The evidence highlights critical developmental windows when environmental insults exert lasting cardiovascular effects and supports incorporating environmental risk reduction into early-life prevention strategies.
Growth-related metrics, particularly low birth weight and preterm birth, emerged as the most consistent correlates of elevated blood pressure and adverse structural phenotypes, and common mechanistic pathways across exposure categories included impaired nephrogenesis, hypothalamic-pituitary-adrenal axis dysregulation,...
Zhuo-Yuan A. Li, Webb A. Smith, A. Walsh et al.· Frontiers in Pediatrics· 0 citations
Cardiovascular disease (CVD) remains a predominant cause of global mortality. The spectrum of traditional risk factors is rapidly expanding, largely driven by the modern cardiovascular exposome. This comprehensive exposome encompasses environmental hazards, sedentary lifestyles, and severe psychosocial stress. Clinical...
Yu-Hang Zheng, Guan-Feng Qin, Zi-Jian Li et al.· Frontiers in Physiology· 0 citations
Background: Preterm birth is increasingly recognized as an early-life exposure with potential cardiovascular consequences across the lifespan. Although improved neonatal care has increased survival among individuals born very and extremely preterm, birth history remains rarely incorporated into cardiovascular risk asse...
M. Patni, Malek Nasrallah, D. J. Al Tarawneh et al.· Medical Science· 0 citations
Atherosclerosis is now recognized as a long-term biological process whose origins may be established early in life, well before the clinical expression of cardiovascular disease. The increasing prevalence of pediatric obesity, insulin resistance, sedentary behavior, and unhealthy dietary patterns has intensified intere...
Citlaly Natali de la Torre-Sosa, Rebeca López-Marure, Héctor Ochoa-Díaz-López et al.· Clínica e Investigación en A...· 0 citations
Childhood obesity has transitioned from an isolated public health concern to a global epidemic in the 21st century. Characterized by excessive adiposity, its etiology is a complex interplay of modifiable environmental factors and non-modifiable somatic conditions. Environmental factors - including screen-time-induced s...
Natalia Szubka· International Journal of Inn...· 0 citations
The first 1000 days of life represent a critical window for renal development and long-term kidney health. During this period, oxidative stress and mitochondrial dysfunction may disrupt nephrogenesis, renal maturation, and redox-sensitive developmental pathways, potentially contributing to reduced nephron endowment and...
L. Pecoraro, A. Signore, A. Dell'anna et al.· Medicina· 0 citations
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