Prenatal nicotine exposure remains a significant public health concern due to persistent tobacco use, electronic nicotine delivery systems, and second‐hand exposure during pregnancy, but existing studies are often compartmentalized by developmental stage, limiting mechanistic integration across prenatal, natal, postnatal, and later‐life outcomes.
Abstract
Prenatal nicotine exposure (PNE) remains a significant public health concern due to persistent tobacco use, electronic nicotine delivery systems, and second‐hand exposure during pregnancy. Epidemiological and experimental evidence has demonstrated that nicotine can readily cross the placenta, disrupt placental development, and interfere with tightly regulated processes of fetal organogenesis. These early perturbations are increasingly recognized as initiating a cascade of structural, functional, and molecular alterations that extend beyond gestation and influence health trajectories across the lifespan. However, existing studies are often compartmentalized by developmental stage, limiting mechanistic integration across prenatal, natal, postnatal, and later‐life outcomes.
Epidemiological evidence suggests that developmental arsenic (As) exposure increases behavioral abnormalities in offspring. However, how placental neuroendocrine function and sex-specific responses contribute to these effects remains poorly understood. Here, we demonstrate that maternal As exposure induces trophoblasti...
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Evidence suggesting how prenatal exposures to alcohol, cocaine, Zika virus, rubella virus, Toxoplasma gondii, influenza, and traumatic brain injury can impact fetal brain development is examined.
Brendan Lujan, Katherine R. Giordano, R. Gonzalez-Ricon et al.· Pregnancy· 0 citations
Longitudinal studies integrating maternal exposures, placental histopathology and molecular phenotypes, fetal organ development, childhood cardiometabolic trajectories and adult clinical outcomes are needed to determine whether, and under what circumstances, the placenta plays an intermediary role rather than merely se...
Fetal neurodevelopment is a critical phase modulated by the maternal microbiome. While certain specific signaling pathways have been identified, the complete signaling network and the spatial and temporal complexity remain largely unknown. Maternal metabolites are essential for fetal growth and certain metabolites are...
M. J. Scoglio, Trinayani Samala, Nasrin Jangjoo Ghalat et al.· Frontiers in Nutrition· 0 citations
Investigating how prenatal exposures, particularly prenatal stress and psychopharmacological exposure, shape fetal neurodevelopment via the placenta-brain axis sheds light on the mechanisms by which environmental stimuli like maternal stress or pharmacology could lead to lasting changes in prenatal health and subsequen...
C. Cruceanu· International Journal of Neu...· 0 citations
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