Association of the Endothelial Activation and Stress Index With Cardiovascular Disease Prevalence and Mortality in Individuals With Rheumatoid Arthritis: First Population‐Based Evidence From the National Health and Nutrition Examination Survey
Jul 2026· Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease· Vol 15· 0 citations· 67 references
Medicine
TL;DR
This study aimed to investigate the association between EASIX and both CVD prevalence and CVD mortality in individuals with RA using a nationally representative sample.
Abstract
Patients with rheumatoid arthritis (RA) are at increased risk of cardiovascular disease (CVD); however, effective risk stratification tools remain limited. The Endothelial Activation and Stress Index (EASIX) is a composite biomarker reflecting endothelial injury and cellular stress, but its association with CVD in populations with RA remains unexplored. This study aimed to investigate the association between EASIX and both CVD prevalence and CVD mortality in individuals with RA using a nationally representative sample.
The association between endothelial activation and stress index (EASIX) and cardiovascular disease (CVD) risk in older adults remains largely unexplored, lacking large-scale evidence. The objective of this study was to examine the association between EASIX and CVD prevalence in the U.S. population aged ≥ 60 years...
In this cross-sectional cohort, disease activity was more strongly associated with AVI than disease duration, and RA disease activity is closely associated with increased arterial stiffness and higher estimated 10-year ASCVD risk.
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Acute cerebral infarction (ACI) is a major cause of global morbidity and mortality, with endothelial dysfunction being a key factor in its pathophysiology. The Endothelial Activation and Stress Index (EASIX) is a novel biomarker reflecting endothelial injury and systemic stress; however, its prognostic role in mortalit...
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