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Open access Sep 2026

The Notch signaling pathway is a master regulator of CD8+ T cell exhaustion and differentiation during chronic infection

It is shown that the absence of Notch signal causes severe CD8+ T cell exhaustion during chronic LCMV infection and demonstrated that Notch signaling is essential to promote the differentiation of Tex progenitors into Tex effector-like cells.

Dave Maurice De Sousa, Salix Boulet, F. Duval et al. · 0 citations
Sep 2026

Rational Engineering of Notch1 Signaling to Boost the Proliferation of CD19-BBζ CAR-T.

A critical role of Notch1 in CAR-T effector function is demonstrated and a novel strategy to augment endogenous Notch1 activity by leveraging native gene regulation is provided to augment endogenous Notch1 activity by leveraging native gene regulation.

M. Phillips, F. Birocchi, Felix Korell et al. · 0 citations
Open access Sep 2026

Antigen-specific regulatory T cells eliminate cognate CD4 effector T cells through perforin, granzyme B, and Bim.

T cells (Tregs) maintain immune tolerance, yet how they selectively eliminate cognate CD4+ effector T cells remains unclear. We propose a co-activation-dependent elimination mechanism, conceptually akin to synthetic lethality. Using in vitro co-cultures, we show that simultaneous peptide-MHC II recognition by Tregs and...

Yan-Yu Ye, Hao-Yue Zheng, Jia-Qi Duan et al. · 0 citations

CRITICAL ROLE OF BIM IN T CELL RECEPTOR RESTIMULATION-INDUCED DEATH

An important role for BIM is suggested in eliminating activated T cells even when IL-2 is abundant, working in conjunction with Fas to eliminate chronically stimulated T cells and maintain immune homeostasis.

Alyssia Snow, Jb. Oliveira, SE Straus et al. · 0 citations
Review Open access Sep 2026

CD4+ cytotoxic T cells: context-dependent effectors in health and disease

This review highlights recent advances in understanding the development, regulation, and effector functions of CD4 + CTLs, while also addressing the limitations and challenges in targeting them therapeutically.

Hao-Yang Yu, Jia-Xin Liang, Qi-Xuan Gu et al. · 0 citations
Sep 2026

Abstract IA005: Determinants of B cell fate and function in cancer

Effector B cell responses in solid malignancies are associated favorable response to immunotherapy. B cells can amplify anti-tumor immune responses via antibody production, antigen presentation, and pro-inflammatory cytokine release; yet B cells in cancer patients and tumor-bearing mice often fail to support these fu...

Y. Pylayeva-Gupta · 0 citations

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