New study suggests viral connection to Alzheimer's disease

Parkinson's-linked gene holds clues to battling deadly bacterial infections

The Alzheimer's disease risk gene SORL1 is a regulator of excitatory neuronal function

Synaptic dysfunction is an early feature of Alzheimer's disease (AD) and proper localization of proteins involved in pre‐ and post‐synaptic composition is dependent on endosomal recycling and trafficking, cellular processes involving the AD risk gene sortilin‐related receptor 1 (SORL1).

Changes in the Structural Network Architecture of LHON Patients' Brains may Reflect more than Just the Progression of the Disease

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Altered Structural Network Architecture in LHON Brains may not only Reflect Progression of the Disease

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Genetic and molecular evidence linking CTSH to Alzheimer's disease pathophysiology

This work investigated how CTSH is regulated and how it influences early AD pathophysiology, and how it influences early AD pathophysiology.

B cells enter the synaptic conversation.

Synapse loss is a defining feature of neurodegenerative disease, yet the signals that orchestrate synaptic elimination remain incompletely understood. Crowley and colleagues uncover an unexpected link between neuronal hyperactivity and adaptive immunity, showing that antibody-secreting B cells and immunoglobulins can d...