AI Networking Cookbook: Practical recipes for AI-assisted network automation and development
Coumarins and their derivatives possess diverse bioactivities and broad applications in pharmaceuticals, food additives, and materials science. For example, amino-functionalized coumarin derivatives hold significant promise for the development of novel functional materials and drug discovery. However, the microbial bio...
Natural products have been paramount in inspiring novel chemistry as well as providing therapeutic agents and chemical tools for biological applications. A recently emerging class of natural products, the thio/seleno-imidazoles (TSIs), contains C–S or C–Se bonds that are installed by nonheme iron sulfoxide and seleno...
Enzyme engineering serves as a powerful tool in biocatalysis, enabling the development of enzymes with improved stability, activity, and specificity for a range of academic, industrial, and pharmaceutical applications. However, a limited understanding of sequence–structure–function relationships in terpene synthases, t...
Sphingomonas represent a significant microbial resource with considerable industrial applicability. However, non-model microorganisms often lack efficient genetic modification tools, which hinders the development of microbial cell factories. In this study, using the welan gum-producing strain Sphingomonas sp. HT-1 as a...
Vanillyl alcohol (VNA) is a high-value compound used in the pharmaceutical industry and other fields. Its microbial de novo biosynthesis is severely limited by the low catalytic efficiency of O-methyltransferase. Here, we constructed a V314I mutant of caffeate O-methyltransferase via structure-guided protein engineer...
Cordycepin is a high-value bioactive compound with significant therapeutic potential. In this study, we report a transposon-based genome engineering strategy for establishing an allantoin-inducible cordycepin production platform in Saccharomyces cerevisiae. We first optimized the allantoin-inducible system by refining...
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