Sep 2026· Journal of Molecular Evolution· 0 citations· 80 references
Medicine
TL;DR
This review synthesizes current knowledge on the role of conserved noncoding elements, human accelerated regions (HARs), and transposable element (TE)-derived sequences in shaping gene regulatory networks (GRNs) underlying brain development to provide a comprehensive framework for understanding the molecular basis of primate brain evolution through the lens of gene regulation.
The argument that focusing on baseline states alone provides a biased view of gene regulatory evolution is supported, and it is suggested that studying gene regulation in dynamic contexts can enrich the authors' understanding of primate evolution.
Arun Durvasula, Amy Longtin, Audrey M. Arner et al.· bioRxiv· 0 citations
Through multiplex, single-cell enhancer assays, HAQERs are identified as active enhancers in the developing brain and cardiomyocytes, and their potential contributions to human-specific gene regulation across multiple tissues are highlighted.
Yan-Ting Luo, Riley J. Mangan, S. Weaver et al.· Cell Genomics· 0 citations
Understanding gene regulation in the brain is essential for defining the genetic basis of neurologic disease. Cis-regulatory elements (CREs) regulate gene expression, but their function and evolution depend on sequence and cis- and trans-regulatory context. We generated single-nucleus RNA- and ATAC-seq data from cortex...
Ashlyn G. Anderson, B. Rogers, Erin A. Barinaga et al.· Cell Genomics· 0 citations
A coordinated evolutionary remodelling of the human skeletal ECM is revealed, including a marked suppression of glycosaminoglycan biosynthesis, leading to an approximately three-to-fourfold reduction in joint GAG content in humans compared with non-human apes.
Yi-Zhi Yan, Nadav Mishol, Katharina Lange et al.· Nature· 1 citation
Deciphering the regulatory consequences of sequence divergence across human evolution is essential to understanding the molecular basis of human-specific traits and disease. Although millions of derived alleles distinguish humans from great apes, only a small fraction are likely to influence human-specific traits. Prev...
Riley J. Mangan, Nikitha Thoduguli, Dimitar Ivanov et al.· bioRxiv· 0 citations
Mammalian brains exhibit extensive diversity in size, cellular composition, and organization, yet the molecular evolutionary changes associated with this phenotypic diversification remain incompletely understood. Here, we investigated whether protein-sequence evolution covaries with quantitative differences in brain ph...
A. Solovyov, M. Kazanskii, Alibek Suraganov et al.· bioRxiv· 0 citations
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