Clinical Outcomes and Prognostic Factors in Uterine Adenosarcoma: A Multicenter Retrospective Cohort Study
TL;DR
Findings suggest that these tumor features may help doctors identify women who require closer follow-up and more individualized postoperative care, in particular, sarcomatous overgrowth and lymphovascular space invasion were linked to poorer outcomes.
Abstract
Simple Summary Uterine adenosarcoma is a rare type of cancer of the uterus. This study looked at the clinical features, treatments, recurrence, and long-term outcomes of 43 women diagnosed with this cancer in seven hospitals in Türkiye between 2016 and 2026. Most women were postmenopausal and had early-stage disease at diagnosis. The most common symptoms were pelvic pain and abnormal uterine bleeding. During an average follow-up of 6 years, about one-third of the women developed a recurrence, most often in the pelvis. Overall, long-term survival was favorable, with about 80% of women remaining alive 5 years after diagnosis. However, certain tumor features were associated with a higher risk of recurrence and death. In particular, sarcomatous overgrowth and lymphovascular space invasion were linked to poorer outcomes. These findings suggest that these tumor features may help doctors identify women who require closer follow-up and more individualized postoperative care.