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Sep 2026

The D389G mutation in E protein attenuates replication and virulence of Japanese encephalitis virus.

Japanese encephalitis virus (JEV) is a mosquito-borne Orthoflavivirus that causes reproductive disorders in pigs and severe neurological sequelae in humans. Although genotypes I (GI) and III (GIII) have been dominant worldwide, the recent emergence of GV in South Korea underscores the urgent need to identify cross-geno...

Sheng-Xian Xiang, Yi-Yang Shi, Cheng-Jie Yang et al. · 0 citations
Open access Sep 2026

Mutations in the macrodomain 1 of nsp3 attenuate PEDV virulence in vivo without impairing in vitro replication

This work provides the first in vitro and in vivo evidence that the conserved N462 residue in the PEDV Mac1 domain is critical for both ADP-ribose binding and hydrolysis, induces IFN production, and contributes to virulence.

Ming-De Liu, Men Thi Hoai Duong, Thamonpan Laocharoensuk et al. · 0 citations
Open access Oct 2026

PEDV Nsp8 alanine-53 promotes viral replication in a partially DTX3L-dependent manner

Porcine epidemic diarrhea virus (PEDV) employs multiple strategies to interact with the host and promote its replication, with nonstructural proteins playing critical roles; however, the underlying mechanisms remain largely unclear. In this study, we found that PEDV infection significantly downregulated DTX3L expressio...

Min Sun, Shi-Yu Liu, Liang Weng et al. · 0 citations
Open access Sep 2026

Unique amino acid substitution within the spike glycoprotein S1 subunit promotes infectious bronchitis virus infection via enhancing viral attachment

This study demonstrated that the expanded cell tropism of CEA, a chicken embryo fibroblast-adapted strain derived from tl/CH/LDT3/03, was related to its enhanced attachment capacity, and established a reverse genetics platform for IBV using circular polymerase extension reaction for the first time.

Tian-Yi Liu, Yu-Juan Zhang, Zong-Xi Han et al. · 0 citations
Open access Oct 2026

A point mutation in duck plague virus gB enhances viral fusogenicity and intercellular dissemination via SNAP25-mediated membrane fusion.

Duck plague virus (DPV) is an alphaherpesvirus that causes significant economic losses to the poultry industry. Glycoprotein B (gB) is the core fusogen mediating membrane fusion during viral entry and cell-to-cell spread, yet the regulatory mechanisms governing gB-induced cell fusion in DPV remain poorly understood. In...

Lin-Jiang Yang, Mao-Fang Du, Ling-Feng Jiang et al. · 0 citations

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