It is indicated that spike protein mutations are involved in the attenuation of GVI-1 IBV strains, and insights into the molecular basis of IBV attenuation during serial passage are provided.
Japanese encephalitis virus (JEV) is a mosquito-borne Orthoflavivirus that causes reproductive disorders in pigs and severe neurological sequelae in humans. Although genotypes I (GI) and III (GIII) have been dominant worldwide, the recent emergence of GV in South Korea underscores the urgent need to identify cross-geno...
Sheng-Xian Xiang, Yi-Yang Shi, Cheng-Jie Yang et al.· Veterinary Microbiology· 0 citations
This work provides the first in vitro and in vivo evidence that the conserved N462 residue in the PEDV Mac1 domain is critical for both ADP-ribose binding and hydrolysis, induces IFN production, and contributes to virulence.
Ming-De Liu, Men Thi Hoai Duong, Thamonpan Laocharoensuk et al.· Journal of Virology· 0 citations
Porcine epidemic diarrhea virus (PEDV) employs multiple strategies to interact with the host and promote its replication, with nonstructural proteins playing critical roles; however, the underlying mechanisms remain largely unclear. In this study, we found that PEDV infection significantly downregulated DTX3L expressio...
Min Sun, Shi-Yu Liu, Liang Weng et al.· Animal Diseases· 0 citations
This study demonstrated that the expanded cell tropism of CEA, a chicken embryo fibroblast-adapted strain derived from tl/CH/LDT3/03, was related to its enhanced attachment capacity, and established a reverse genetics platform for IBV using circular polymerase extension reaction for the first time.
Tian-Yi Liu, Yu-Juan Zhang, Zong-Xi Han et al.· mBio· 0 citations
Duck plague virus (DPV) is an alphaherpesvirus that causes significant economic losses to the poultry industry. Glycoprotein B (gB) is the core fusogen mediating membrane fusion during viral entry and cell-to-cell spread, yet the regulatory mechanisms governing gB-induced cell fusion in DPV remain poorly understood. In...
Lin-Jiang Yang, Mao-Fang Du, Ling-Feng Jiang et al.· Poultry Science· 0 citations
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