AI Networking Cookbook: Practical recipes for AI-assisted network automation and development
TL;DR
Network analysis identifies IRAK1, TRAF6, and MAPK1 as an integrated signalling core, with CXCL8 as an inflammatory downstream effector, which further supports the biological plausibility of CXCL8 induction in CAD.
HLA-G, HLA-A, HLA-C, and B2M modulate macrophage and T cell functions, driving immune dysregulation in AS, highlighting the potential of these molecules as diagnostic biomarkers and therapeutic targets.
Purpose: Atherosclerosis is a chronic inflammatory disease characterized by lipid accumulation within the arterial wall and immune dysregulation. Reliable immune-related biomarkers for early diagnosis and disease severity assessment remain limited. This study aimed to investigate the association between CD56 (NCAM1) ge...
BACKGROUND Chronic kidney disease (CKD) involves persistent low-grade inflammation that perpetuates kidney injury. Toll-like receptor 9 (TLR9), an innate-immune sensor of unmethylated CpG and mitochondrial DNA, may contribute to this process, but its peripheral-blood expression in CKD remains unclear. METHODS In a cr...
The aim of the present study was to identify serum proteins associated with atherosclerosis and its comorbidities. The 3-year follow-up included 216 patients subjected to coronary angiography. Gensini score was used to quantify coronary atherosclerosis, and peripheral atherosclerosis was assessed by B-mode ultrasound...
Background: The systemic inflammatory and angiogenic milieu is a critical determinant of hepatocellular carcinoma (HCC) progression. This study aimed to develop and validate a comprehensive prognostic model based on a quartet of key circulating cytokines: Interleukin6- (IL6-), IL8-, IL10-, and Vascular Endothelial Grow...
Chronic vascular endothelial inflammation plays a pivotal role in the pathogenesis of coronary artery disease (CAD). N6-methyladenosine (m6A), the predominant epitranscriptomic modification in messenger RNA (mRNA), regulates pro-atherogenic inflammatory responses in coronary endothelial cells. This study explores the r...
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