Overall, this work suggests a contributing role of H3R in modality-specific effects on sensory processing through its enrichment in specific neuronal populations in DRG.
BACKGROUND
Neuropathic pain, a debilitating chronic condition, remains a major clinical challenge due to its complex pathogenesis and limited treatment options. Protein tyrosine phosphatase 1B (PTP1B), a key regulator of tyrosine phosphorylation, has been implicated in various diseases, yet its specific role and mechan...
Xiao-Qin Li, Shu-Jin Wu, Rui-Li Sun et al.· Regional anesthesia and pain...· 0 citations
Chronic pain affects more than one-fifth of adults in the United States and represents a major public health burden due to its impact on quality of life, productivity, and healthcare costs. Current pharmacological treatments remain limited in efficacy and are often associated with significant adverse effects, highlight...
Alex D. Chapman, Katherine L. Black, G. Leinninger et al.· Frontiers in Pharmacology· 0 citations
ABSTRACT
Spinal cord stimulation (SCS) is a clinically approved therapy for neuropathic pain (NP), yet a substantial subset of patients fails to respond or shows minimal efficacy, so-called nonresponders. It remains unclear how to resolve this SCS nonresponsiveness. Using a NP model induced by tibial-sparing nerve inju...
Zhao-Li Luo, Jing Liu, Xiang Cui et al.· Pain· 0 citations
It is demonstrated that dopaminergic neurodegeneration initiated within the brain is sufficient to drive persistent peripheral sensory neuron dysfunction and identify CRMP2-dependent regulation of NaV1.7 as a therapeutic target for Parkinsonian pain.
Tyler S. Nelson, Naomi K. Grabus, Heather N. Allen et al.· bioRxiv· 1 citation
Highlights What are the main findings? SNI induces a distinct STAT1-associated IFN SGC population in the DRG, characterized by increased CXCL10 expression. This SGC inflammatory program is associated with sensory-neuron hyperexcitability and pain hypersensitivity. Local STAT1 inhibition or CXCR3 blockade alleviates pai...
The results support the CRMP2-Nav1.7 axis as a promising therapeutic target while highlighting the need to define how peripheral and central adaptations interact to shape persistent facial pain.
Heather N. Allen, Naomi K. Grabus, Rajesh Khanna· bioRxiv· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.