Temporal dynamics of EEG microstates during postural control in Parkinson's disease.

Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterised by motor impairments extending to balance and postural regulation. Although EEG abnormalities in oscillatory activity and functional connectivity are well documented in PD, large-scale brain dynamics during tasks directly engaging postural control remain poorly understood. To address this gap, we examined EEG microstate organisation during the BioVRSea virtual-reality postural-control task in early-stage PD patients (n = 30) and matched healthy controls (HC; n = 26). EEG microstates, brief quasi-stable scalp topographies representing global neural states, provide a robust framework for characterising the rapid temporal structure of whole-brain activity. Although task-based microstate approaches exist, applications to PD remain limited and largely confined to resting-state research. Topographical analyses revealed pronounced between-group differences in microstates D and E, whose group-averaged maps in PD diverged markedly from canonical configurations. Because these maps were not topographically equivalent between groups, comparisons of temporal parameters were restricted to the comparable microstates A-C. Across all task phases, PD patients showed increased duration and coverage of microstates A and B. Transition-probability analysis, likewise restricted to A-C, indicated different trajectories across phases in PD and HC. A single significant Group × Phase interaction emerged for A→C: the largest between-group difference occurred during the POST-movement phase, when PD showed a higher probability than HC. For the remaining transitions, no phase-dependent differences emerged within PD. Because patients were assessed ON medication and clinical or behavioural correlates were unavailable, these findings represent candidate task-state EEG microstate alterations requiring validation, rather than established disease-specific markers.