Dexmedetomidine Alleviates Cardiomyocyte Senescence Induced by Ischemia-Reperfusion Injury via Inhibiting the MDH2/NF-κB Pathway.

Bisdemethoxycurcumin Alleviates Myocardial Ischemia/Reperfusion Injury by AMPK-mediated Autophagy Activation and Apoptosis Suppression.

Myocardial ischemia/reperfusion (I/R) injury impairs the prognosis of patients with cardiovascular disease. Reperfusion induces cardiomyocyte apoptosis and dysregulates autophagy, thereby disrupting cellular homeostasis and exacerbating myocardial injury. Bisdemethoxycurcumin (BDMC), a major active component of Curcuma...

Kisspeptin-10 alleviates OGD/R-induced H9c2 cardiomyocyte injury by triggering autophagy via regulating the YY1/TFEB axis

Endothelial cell-derived MYDGF alleviates cardiomyocyte injury in rats after ischemia/reperfusion.

INTRODUCTION Crosstalk in the heart is essential for normal cardiac development and disease progression. We explored the potential cardioprotective effects of endothelial cell-derived myeloid-derived growth factor (MYDGF) on the myocardium during ischemia/reperfusion (I/R) injury. METHODS Rat H9C2 cardiomyocytes and...

Knockdown of VNN1 protects cardiac myoblasts from hypoxia/reoxygenation injury via the PI3K/Akt pathway.

Myocardial ischemia/reperfusion (I/R) injury is a critical factor contributing to adverse outcomes following infarction, primarily due to oxidative stress, inflammation, and cardiomyocyte death. Vanin-1 (VNN1), a pantetheinase enzyme involved in redox regulation, has recently emerged as a potential mediator of tissue d...

Remimazolam attenuates myocardial ischemia/reperfusion injury by inhibiting ferroptosis involving the AKT/SLC7A11/GPX4 axis

Remimazolam (RMZ) is an ultra-short-acting sedative anesthetic that provides protection against cerebral and hepatic ischemia/reperfusion injury. However, its potential cardioprotective effect in myocardial ischemia reperfusion injury (MIRI) remains to be fully elucidated. The present study investigated the hypothesis...

Eucalyptol Mitigates Isoproterenol-Induced Myocardial Injury in Rats via Activation of p38 MAPK/JNK Signaling, Suppression of ER Stress, and Modulation of Apoptotic Pathway.

BACKGROUND Myocardial injury (MI), a subset of cardiovascular diseases, remains a leading cause of deaths globally, driven by pathological inflammation, oxidative stress, and apoptotic cell death. Despite advances in interventional cardiology, high relapse rates and therapeutic limitations underscore the urgent need fo...