City Research

The hippocampus and cortical memory networks have an inflection point in middle childhood

Connections within a network that supports semantic memory matures early, but connectivity between this network and hippocampus does not mature until at least 7-years of age, identifies 7-years as a developmental inflection point in both hippocampal signaling and hippocampal-cortical memory interactions that may suppor...

Different hippocampal subfield volumes predict source memory performance and general cognitive ability in an adult lifespan sample

Neuroimage: Reports

Structural Connectivity Between the Retrosplenial Cortex and Hippocampus in the Healthy Human Brain: A Diffusion Tensor Tractography Study.

BACKGROUND/PURPOSE The retrosplenial cortex (RSC) and hippocampus are important regions involved in spatial navigation by integrating vestibular information into spatial representations. Although functional interactions between these regions have been demonstrated, there is currently a lack of evidence regarding the st...

Multiscale Organization of Amyloid-Associated Vulnerability Across the Hippocampal Memory System.

Alzheimer's disease (AD) selectively affects interconnected components of the hippocampal memory system, yet most MRI biomarkers characterize neurodegeneration using whole-hippocampal or isolated regional measurements. We tested whether amyloid-associated structural vulnerability is selectively concentrated in the corn...

High‐Resolution Diffusion Tensor Imaging of the Hippocampus and Associations With Neuropsychiatric Symptoms in Lewy Body Diseases

Lower hippocampal fractional anisotropy in the LBD spectrum relative to HC potentially reflects microstructure alterations; however, higher hippocampal FA in LBD with more severe depression suggests more complex microstructural changes such as altered synaptic density, Lewy neurite organization, or neuroplastic changes...