TL;DR
The genome-wide methylome and transcriptome of clinically healthy beagle dogs representing three distinct age groups showed partially overlapping but distinct hallmark associations, suggesting links to different age-related biological processes.
Analysis of DNA methylation in mammalian blood reveals fundamental links between epigenetic regulation during development, aging, and chronic diseases and develops epigenetic clocks that predict expected mortality across species and tissues and are effective in detecting a range of disease models.
Cumulative mitotic history showed a stronger association with epigenetic noise than chronological age, explaining most of its variance particularly within CpG-rich regulatory regions, while genomic context modulates regional vulnerability to methylation information loss during aging.
It is found that tubular epithelial cells in diseased kidneys exhibit pronounced accelerated epigenetic aging and it is shown that this pathological state mirrors transcriptional trajectories observed during aging, driven by preferential dysregulation of lineage-specific genes lacking CpG islands.
A single-nucleus multi-omics analysis of the hypothalamus in young, middle aged, and aged male and female mice highlights distinct cell-type-specific aging trajectories in the male and female hypothalamus, identifies female aging signatures associated with X-linked epigenetic regulatory programs, and provides a compreh...
Partial evolutionary preservation of age-related methylation behavior at human OBS-associated loci is suggested, providing a comparative framework for redox-related epigenetic dynamics.
Background/Objectives: Among the many proposed theories of aging, a growing body of research points to epigenetic alterations, particularly changes in DNA methylation patterns, as key contributors to biological decline. DNA methylation can be targeted and modulated to induce anti-aging and regenerative effects using an...
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