A dual-functional dendrimer-based system integrating recombinant endolysin and cinnamic acid for enhanced endolysin stability and antibacterial activity against Acinetobacter baumannii
Sep 2026· World Journal of Microbiology & Biotechnology· Vol 42· 0 citations· 55 references
Medicine
TL;DR
A dual-component SPION-based platform improved the functional stability and antibacterial performance of immobilized PlyF307, highlighting its potential for antimicrobial nanobiotechnology applications.
Antimicrobial photodynamic therapy (aPDT) is a promising alternative for combating multidrug‐resistant bacteria and overcoming limitations of conventional antimicrobial treatments. To improve aPDT performance, two Protoporphyrin IX (PpIX) derivatives functionalized with one or two capsaicin fragments were synthesized a...
I. V. da Cunha, G. G. Calefi, N. B. S. Silva et al.· ChemMedChem· 0 citations
Escherichia coli-derived l-asparaginase (EcA) is a crucial frontline therapy for the treatment of acute lymphoblastic leukemia (ALL), yet its use in clinical settings remains considerably compromised due to its immunogenicity, hypersensitivity reactions, hepatotoxicity, rapid proteolytic degradation, and a markedly s...
B. Nayak, Sukanya Samanta, Sayantan Sarkar et al.· Bioconjugate chemistry· 0 citations
The utilization of endophytes as specialized microbial cell factories offers a sustainable and high-efficiency platform for the biosynthesis of functionalized nanomaterials. This study investigates the potential of a novel endophytic yeast, Clavispora lusitaniae, to produce cerium oxide nanoparticles (CeO₂NPs) and eval...
Hoda S. Nouh, Nessma A. El-Zawawy, Shimaa El-Sapagh et al.· Microbial Cell Factories· 0 citations
The observed physiological and transcriptomic responses provide molecular evidence associated with the improved antibacterial performance of tFNQ and support the potential application of tFNAs-based co-delivery strategies for antimicrobial intervention.
Jiuyan Zhang, Rui-Yuan Shi, Jia-Jian Liang et al.· Critical reviews in food sci...· 0 citations
Peptide dendrimers, characterized by their branched structure and densely arrayed surface amino acids or peptides, offer enhanced multivalency and unimolecular stability that collectively improve receptor engagement and bioactivity. Despite these advantages, broad application remains limited due to synthetic complexity...
An Yan, Tianyu Zhang, Xing-Yu Wang et al.· Acta Biomaterialia· 0 citations
Background/Objectives: In this study, ZIF-8 and silibinin-loaded ZIF-8 nanostructures containing different concentrations of silibinin were successfully synthesized using a one-pot method and characterized by FT-IR, SEM, and EDX analyses. Methods: The antibacterial activities of the synthesized nanostructures were subs...
Başak Bedir, M. Erşatır, M. Çimentepe et al.· Antibiotics· 0 citations
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