Sep 2026· Naunyn-Schmiedeberg's Archives of Pharmacology· 0 citations· 38 references
Medicine
TL;DR
Results indicate that perimidine-based molecules, particularly Compound 101 and Compound 201, are promising compounds towards the development as EGFR-targeting anticancer drugs; however, further biochemical and cellular target-validation studies are required to confirm direct EGFR inhibition and their therapeutic potential.
G856-6814 is supported as a NAT10-targeting inhibitory scaffold that requires broader selectivity and in vivo evaluation and attenuation of cellular effects after NAT10 knockdown.
Chao Xu, Shi-Lei Zhao, Bing Xu et al.· Journal of Computer-Aided Mo...· 0 citations
Background/Objectives: Cancer remains one of the leading causes of mortality worldwide, demanding the discovery of safer and more effective therapeutic agents. Methods: In this study, a comprehensive coumarin derivative library containing 2,681 compounds was compiled from literature and online chemical databases. After...
A. Pandey, Anuvanshika Yadav, Anupam Tiwari et al.· Biological sciences· 0 citations
The results identify Cardenolide as a computationally prioritized candidate with favorable predicted EGFR-binding characteristics, structural stability, and physicochemical and toxicity profiles and illustrate the potential of Adenium obesum phytochemicals as a source of candidate EGFR-targeting compounds for future NS...
Md. Naziur Rahman, Abu Yousuf Hossin, S. Talukder et al.· PLoS ONE· 0 citations
The potential therapeutic relevance of structurally novel EGFR-targeting scaffolds in OSCC is suggested and a foundation for future experimental validation through in vitro and in vivo studies is provided.
Muhammad Bilal Azmi, Tehreem Zia, Uzma Asif et al.· In Silico Pharmacology· 0 citations
Overall, the combined computational and biological findings suggest that amino quinoxaline scaffolds indicate potential avenues for enhanced optimization as EGFR-targeted anticancer drugs.
Abitha H, D. Kumudha· Oriental Journal of Chemistr...· 0 citations
The utility of structure-based virtual screening combined with ADMET prediction as an effective strategy for early-stage lead identification in prostate cancer drug discovery and the improved predicted pharmacokinetic properties suggest that rational modification of heterocyclic scaffolds can yield AR antagonists with...
Vanktesh Kumar, Shivank Sharma, Saminesh Kumar et al.· Current Organocatalysis· 0 citations
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