An immunophenotype-coupled transcriptomic atlas of mouse hematopoietic progenitors

The lifelong transcriptomic landscape of human blood cells.

A panoramic landscape of the human hematopoietic system is established and its lifelong behaviors are elaborated, in which a steady-state reference enabled the delineation of pathological hallmarks across hematological malignancies.

Transcriptional landscape of canine hematopoiesis and cross-species comparisons revealed by single-cell RNA sequencing

This study provides a high-resolution transcriptional atlas of canine hematopoiesis and highlights conserved regulatory programs between dogs and humans, offering a reference for future studies of hematologic disease and cross-species comparisons.

Functional heterogeneity of mouse fetal liver hematopoietic stem cells revealed by clonal lineage tracing and single-cell transcriptomics.

A clonal-resolution view of fetal liver HSC heterogeneity is provided, enhancing the understanding of HSC diversity across different developmental stages and suggesting a specific coupling relationship between transcriptional persistence and lineage bias.

Preliminary transcriptome profiling of induced pluripotent stem cell-derived hematopoietic stem and progenitor cells in Kawasaki disease

iPSC-derived HSPCs from patients with KD display altered immune-inflammatory transcriptional profiles and suppressed B-cell developmental signatures at the transcriptomic level, which suggest that early hematopoietic immune dysregulation may contribute to KD pathogenesis.

Immunophenotyping by Single-Cell CITE-Seq.

Single-cell multiomics reveals exosome-mediated reprogramming and clonotypic remodeling of T cells in triple-negative breast cancer

A comprehensive single-cell multiomic analysis of primary human T cells exposed to exosomes derived from 17 genomically diverse TNBC cell lines and 35 patient samples uncovered conserved and subtype-specific immunomodulatory programs induced by TNBC exosomes.