TL;DR
These findings support a model in which racR silencing activates a prophage-host stress circuit interlinking inner membrane energetics, activation of envelope stress, cell division control, and heterogeneous recovery.
Abstract Exposed single-stranded DNA (ssDNA) accumulating at stalled or collapsed replication forks (RFs) can trigger the replication stress response (RSR) to prevent genome instability. Leishmania are parasitic eukaryotes whose plastic genomes facilitate rapid adaptations under stress, with intrinsic replication stres...
TnpB nucleases, the evolutionary progenitors of CRISPR-associated Cas12 enzymes, are transposon-encoded, RNA-guided endonucleases found throughout bacteria. Independent of the trajectory towards adaptive immunity, TnpB nucleases have also recurrently given rise to TnpB-like nuclease-dead repressors (TldRs), a family of...
Cell division is an essential process for an organism that is orchestrated by many proteins, and its disruption can lead to cell death. The cell division process could be a promising target for a novel antibiotic, particularly against a hard-to-treat pathogen such as Mycobacterium abscessus (MAB). FtsL is a highly cons...
Heterochromatin loss disrupts nuclear architecture, gene regulation and repetitive element silencing, and is associated with diverse human diseases. However, mechanisms linking heterochromatin dysfunction to pathological phenotypes remain unclear. Using genetic interaction screening and genomic analyses in C. elegans,...
The bacterial SOS response promotes DNA repair, survival, and mutagenesis under genotoxic stress, especially during sub-lethal antibiotic exposure. This response is regulated by LexA, a transcriptional repressor controlling SOS gene expression, but how LexA coordinates this network as antibiotic stress alters nucleoid...
Bacterial persistence enables a phenotypically tolerant subpopulation to survive lethal antibiotic exposure, contributing to the recalcitrance of chronic infections and facilitating the evolution of heritable resistance. Despite its importance, a systems-level, quantitative understanding of how transcriptional regula...
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