Integrated UPLC-MS/MS profiling and network pharmacology-based analysis of the anti-hyperglycemic potential of Baihu Jia Renshen Decoction combined with Sanghuangporus vaninii extract in mice

Integrated network pharmacology, molecular docking, ADMET profiling and In vitro α-amylase inhibitory evaluation of Cardiospermum halicacabum Linn. Against diabetes mellitus

Integrating Network Pharmacology and Metabolomics to Decipher the Mechanisms Underlying the Therapeutic Effects of Wuzhi Dripping Pills Against MASLD

Background: Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is a progressive condition predisposing to cirrhosis and hepatocellular carcinoma, with prevalence rising globally. Yet effective therapies remain limited. Wuzhi Dripping Pills (WZDP), derived from Schisandra sphenanthera, possess hepatoprotec...

Combining network pharmacology and experimental validation to explore the therapeutic mechanism of Banxia Xiexin decoction in type 2 diabetes mellitus

BXXD alleviates T2DM-associated metabolic dysregulation by activating the AMPK/SIRT1-mitophagy axis and suppressing inflammation, providing mechanistic evidence supporting further translational investigation of BXXD for T2DM.

Integrated UHPLC-MS/MS Metabolomics, Network Pharmacology, Molecular Docking, and Experimental Validation Reveal the Anti-Inflammatory Mechanisms of Pyrus pyrifolia Peel Extract

Pyrus pyrifolia (Burm. f.) Nakai has long been utilized in traditional East Asian medicine to treat respiratory disorders, fever, cough, and inflammatory conditions. This study aimed to evaluate the antioxidative and anti-inflammatory effects of P. pyrifolia. UHPLC-MS/MS analysis revealed that P. pyrifolia contained 22...

Exploration of Active Compounds and Potential Mechanisms of Ginseng Dripping Pills: An Integrated Study Utilizing UHPLC‐Q‐Orbitrap MS Analysis and Network Pharmacology

Ginseng dripping pills (GDPs), a traditional Chinese patent medicine, are extensively used for cardiovascular diseases (CVDs), but their active components and underlying mechanisms remain unclear. This study aimed to identify the chemical constituents of GDP and to explore their potential mechanisms in treating myocard...

Antioxidant Activity and Anti-Inflammatory Potential of Rhododendron dauricum Flowers via UPLC-Q-TOF-MS/MS Combined with Network Pharmacology and In Vitro Validation

Rhododendron dauricum L. flowers are highly valued as ornamental plants in northern Chinese horticulture, yet while its leaves are well-known for their antitussive and anti-asthmatic effects, the flowers themselves remain an underutilized resource. Oxidative stress and chronic inflammation are intimately intertwined pa...