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Computational and experimental evaluation of curcumin as a DNMT3B-targeting epigenetic modulator in pancreatic cancer

Ali Afgar Saeed Zanganeh R. Mirzaee Khalilabadi T. Haghpanah Mostafa Amopour Bahnamiry Hoda Ebrahimi Mohamad Javad Mirzaei-Parsa Batoul Kavyani

Sep 2026 · In Silico Pharmacology · Vol 14 · 0 citations · 32 references

Medicine

TL;DR

Findings underscore curcumin’s dual role as an epigenetic modulator (via miR-29b/DNMT3B/MUC1) and ROS inducer, offering a promising strategy for targeted pancreatic cancer therapy.

DOI PubMed Semantic Scholar

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