This work analysed 939 cyanobacterial genomes spanning 11 orders and five habitat types to identify taxonomic and ecological hotspots of biosynthetic potential and link phylogeny, ecology and genomic features to prioritise taxa, habitats and biosynthesis pathways for future natural product discovery.
Comparative genomic and biosynthetic analyses of 24 Talaromyces species reveal extensive diversification alongside selective conservation of secondary-metabolite pathways across Talaromyces and provide a genomic framework for prioritizing species and BGCs for antifungal natural-product discovery and biocontrol-oriented...
B. Chellappan, Hashem Al-Sheikh· Journal of Fungi· 0 citations
The new release of BGC Atlas v2 provides taxonomic assignments for nearly all BGCs, harmonized environmental metadata, nested searches across biosynthetic, taxonomic, environmental and geographic properties, and protein-sequence searches against BGC-encoded genes.
Caner Bağcı, Alec Talamas-Tanner, N. Ziemert· bioRxiv· 0 citations
It is demonstrated that environmental filtering shapes both the taxonomic and functional organization of Antarctic microbiomes and highlight polar ecosystems as reservoirs of unexplored biosynthetic diversity with potential biotechnological relevance.
William B. Medeiros, Kelly Hidalgo-Martinez, D. D. P. S. Penna et al.· World Journal of Microbiolog...· 0 citations
The isolation of a novel Jiangella strain reported from a marine, animal-associated plastisphere is described and its biosynthetic repertoire is placed in the context of the whole genus, providing a genome-based prioritization of candidate biosynthetic targets.
Ruggero Baviera, F. Capri, Paola Galluzzo et al.· Marine Drugs· 0 citations
It is demonstrated that microbial adaptation to extreme environments favors RiPP-based biosynthesis and that HCN may play a role in archaeal ecological interactions, and microbial communities in Arctic hydrothermal vent biofilms provide a rich reservoir of unique bioactive compounds, with implications for drug discover...
Thuc Trong Nguyen, I. H. Steen, R. Stokke· Nature Communications· 0 citations
The effectiveness of integrated genome-mining strategies for prioritizing cryptic biosynthetic gene clusters is demonstrated and the remarkable biosynthetic potential of newly identified Streptomyces isolates as a source of novel natural products is highlighted.
Nada S. Al-Theyab, Haila M. Alnassar, Mohanad A. Ibrahim et al.· Frontiers in Microbiology· 0 citations
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