Integrated single-cell and spatial transcriptomic analyses reveal malignant epithelial glycolytic heterogeneity and spatial niche remodeling during colorectal cancer progression

Jin-Yu Xiao Shan-Shan Heng Jia-Yu Li Shao-Zhuo Xie Liang-Zhi Li Jia-Jia Chen Jie Wu Yu-Xin Lin Xin Qi

Sep 2026 · Functional & Integrative Genomics · Vol 26 · 0 citations · 61 references

Medicine

TL;DR

Findings indicate that glycolytic heterogeneity is a key feature of CRC malignant epithelial cells and is closely associated with tumor progression, microenvironmental remodeling, and clinical outcomes.

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