Aug 2026· Journal of Molecular Evolution· 0 citations· 53 references
Medicine
TL;DR
The view that glycerol-based backbones could have participated in early proto-nucleic-acid chemistry is supported and phosphate may have been selected not because arsenate analogues were thermodynamically unstable, but because phosphate-based backbones were more kinetically persistent and more resistant to hydrolysis than arsenate-based ones.
Molecular dynamics simulations use molecular dynamics simulations to investigate the differences in hydrogen-bonding interactions and conformational motions between the preturnover and midturnover states and provide insights into the critical role of conformational motions and flexibility in regulating PCET reactions a...
Matthew Tremblay, Sharon Hammes-Schiffer· Biochemistry· 0 citations
The phosphorylation of nucleosides and their subsequent polymerization are key issues in the study of the Origins of Life. How these chemical processes took place on primitive Earth remains a puzzle. In this study, we examine the thermal phosphorylation of guanosine in water under wet-dry conditions and in the presence...
Martina Proietti, B. M. Bizzarri, E. De Marchi et al.· Chemistry· 0 citations
Adenosine-5'-triphosphate (ATP) can accumulate to near-molar concentrations within specific biological compartments, influencing a diverse range of cellular processes. However, its structural organization and molecular dynamics under these crowded conditions remain poorly understood. In this study, ATP gel systems cont...
It is concluded that the early emergence of the Rossmann fold reflects the chemical and physical constraints of protein folding, explaining both its profound antiquity and sustained longevity.
Koh Seya, Tatsuya Corlett, Hamza Giaffar et al.· bioRxiv· 0 citations
How did phosphate become the universal energetic currency of life? Traditional approaches to phosphorylation in early evolution studies entail non-physiological conditions. Phosphite, HPO32-, which is oxidized enzymatically by many microbes and which naturally occurs in serpentinizing hydrothermal vents, readily phosph...
Nadja K. Hoffmann, M. L. Schlikker, W. F. Martin· Biochimica et Biophysica Act...· 0 citations
Hydrogen bonding and hydrophobic stacking are the primary interactions that control the structure and functionality of DNA systems, including those of most synthetic variants. These interactions are weak and are highly dynamic. Tunable Orthogonal Reversible Covalent (TORC) bonding utilizes dynamic covalent interactions...
Phuoc H. T. Ngo, Wesley Oliver, Priyalatha M. Kirisenage et al.· Journal of the American Chem...· 0 citations
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