Sep 2026· Medical Oncology· Vol 43· 0 citations· 70 references
Medicine
TL;DR
Overall, this review provides a comprehensive overview of the design, synthesis, functionalization, therapeutic applications, pharmacokinetics, biodistribution, safety profiles, and clinical translation potential of folate-functionalized chitosan NPs for precision cancer therapy.
ChNPs can deliver anticancer drugs to thyroid carcinoma cells with greater selectivity by utilizing both active targeting through ligand-mediated interactions and passive targeting through the increased permeability and retention effect.
In vitro and in vivo studies further demonstrated the potential of this nanoparticle system for controlled, targeted, and biocompatible delivery of anticancer agents.
Madhusudan Maity, Niranjan Panda, Subas C. Dinda et al.· Recent Patents on Nanotechno...· 0 citations
This review provides an overview of nanoparticle-based targeted drug delivery in cancer therapy, with emphasis on passive and active targeting mechanisms, major nanoparticle platforms, therapeutic applications, current challenges, and prospects for clinical translation.
G. Patil, Kartik Parmar, Kavita Rana· Journal of Drug Delivery and...· 0 citations
Polysaccharide-based colon-targeted drug delivery systems provide safer, more effective, and more personalized treatment with continued research to optimize delivery and overcome existing limitations.
Tan-Wan Yi, Pankaj Kumar, R. Karwasra et al.· Journal of Visualized Experi...· 0 citations
Tamoxifen remains a cornerstone in the treatment of estrogen receptor-positive breast cancer, yet its clinical performance is limited by poor aqueous solubility, high lipophilicity, and interindividual variability associated with CYP2D6-mediated formation of its more potent active metabolites. These challenges necessit...
In conclusion, while nanocarriers offer significant advancements in targeted cancer therapy, their successful clinical implementation depends on overcoming various scientific, technical, and regulatory challenges.
Busayo Olamide Tomoh· International Journal of Med...· 0 citations
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