Agitated filter dryers (AFDs) are a crucial unit operation in small molecule manufacturing that enables simultaneous filtration, washing, and drying of active pharmaceutical ingredients. One of the key challenges in AFDs is associated with undesired agglomeration, where the presence of hard agglomerates results in off-spec products, equipment damage, and additional downstream processing. This article presents a novel mechanistic model that describes the formation of soft and hard agglomerates during agitated filter drying. By integrating population balance and multiphysics modeling, the model can accurately predict the evolution of the product temperature, moisture content, and particle size distribution, and hence quantify the extend and impact of undesired agglomeration across various operating conditions. Our proposed model-based framework enables the rational design and operation of AFDs for improving the product quality and process reliability.
Wet granulation is a critical unit operation in the manufacturing of solid dosage forms. However, conventional wet granulation techniques are limited by significant batch-to-batch variability and scale-up challenges, making them difficult to meet the demands of continuous pharmaceutical manufacturing and robust quality...
Min Niu, Yi-Fan Hu, Liping Chen et al.· International journal of pha...· 0 citations
Wet milling is a critical operation in drug substance manufacturing, enabling control of the particle size distribution of active pharmaceutical ingredients. Scaling up of the wet milling process usually involves equipment change. Due to material availability limitations during the early stage of development, there i...
Kensaku Matsunami, Álmos Orosz, Varun Sundarkumar et al.· Organic Process Research
&am...· 1 citation
Energy-efficient and cost-effective direct air capture of CO2 is considered key for carbon dioxide removal and carbon capture and utilization. However, separating CO2 from air is inherently challenging due to its low concentration and fluctuating humidity levels. Polymer-based chemisorbents combine good selectivity a...
Francesco Maria Bellussi, Paweł P. Ziemiański, I. Sadykov et al.· ACS Sustainable Chemistry &a...· 0 citations
Limited options for feedstocks have historically inhibited the growth of polymer powder bed fusion (PBF), a promising additive manufacturing (AM) technology, and created a demand for versatile, low-cost, and sustainable feedstock powders. In this study, we report the creation of a high-value feedstock for PBF from post...
Mahmudul Hasan, Mark D. Dadmun· Journal of Chemical Physics· 0 citations
The continuous increase in atmospheric CO2 emissions from industrial and energy related activities has intensified climate change concerns and highlighted the need for efficient adsorbent materials for carbon capture applications. This work focuses on the simulation and optimization of the CO₂ adsorption process by Des...
Mohammed R. Abed, A. Wiheeb· Samarra Journal of Engineeri...· 0 citations
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