AI Networking Cookbook: Practical recipes for AI-assisted network automation and development
TL;DR
Findings establish that both catalytic and allosteric sites play essential roles in regulating 3CL pro function, and targeting allosteric regions such as the Asn28-associated pocket offers a promising approach for antiviral development.
The findings provide mechanistic insights into a key allosteric mechanism for Mpro inhibition but also provide a promising chemical scaffold for further development as an Mpro-targeting inhibitor.
It is demonstrated that targeted protein degradation can effectively induce the degradation of 3CPro in picornaviruses, supporting the development of resistance‐resistant, broad‐spectrum antiviral agents and highlighting their potential to address evolving viral threats.
It is demonstrated that nanobodies targeting the PLpro/ISG15 interface can achieve synergistic antiviral and immunomodulatory effects, providing a proof-of-concept for a novel therapeutic approach to combat SARS-CoV-2 and potentially other emerging coronaviruses.
A rapid drug development platform that integrates covalent docking with direct-to-biology (D2B) synthesis and screening to identify nsP2 inhibitors is presented, which establish a streamlined strategy for covalent inhibitor development and provide promising leads for CHIKV antiviral development.
A covalent pan-coronaviral inhibitor that targets 19 Mpros across the α, β, γ, and δ genera, encompassing bat, human, and other animal coronaviruses, AVI8122 exhibits low nanomolar potency and favorable pharmacokinetics in mice and is positioned as an early lead compound and a tractable structural starting point for th...
Data is presented showing that 17AAG covalently binds to the active‐site cysteine of Mpro, disrupts its secondary structure, and protects cells from Mpro‐induced toxicity more effectively than nirmatrelvir.
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