Findings support a role for USGs in the genetic architecture of SZ and suggest that common variation within this system may link genetic susceptibility to neurodevelopmental processes and cognitive heterogeneity in SZ.
A high-resolution cellular and temporal framework of SZ susceptibility is established, implicating mature associative IT microcircuits, deep-layer thalamocortical-regulating networks, and early developmental specification windows as primary points of genetic convergence in SZ.
Yong Wu, Yuan Gao, Miao Li et al.· Molecular Psychiatry· 0 citations
A systematic consolidation of current evidence supporting the involvement of CNNM2 in SCZ pathogenesis provides a direction for further investigation of the pathological mechanisms underlying this disease, and for identification of novel targets for clinical intervention.
Yang Jin, Li-Ge Zhang, Xiaoyi Yao et al.· Neuroscience· 0 citations
A population-scale single-cell transcriptomic atlas of the human dorsolateral prefrontal cortex provides a perspective of the transcriptomic landscape in neurodegenerative and neuropsychiatric disorders, and offers potential targets for therapeutic intervention.
Donghoon Lee, Mikaela Koutrouli, Nicolas Y. Masse et al.· Nature· 8 citations
A reorganization of molecular networks in schizophrenia is demonstrated, with alterations in the micro-architecture of molecular couplings, strengthening the importance of investigating functional interactions among molecules, as such analyses may reveal significant alterations in schizophrenia that cannot be detected...
G. De Simone, T. Nuzzo, A. di Maio et al.· International Journal of Neu...· 0 citations
Autism polygenic load broadened modular network configurations in males without shifting mean organisation or its behavioural correlates, offering partial support for landscape accounts of neurodevelopmental diversity.
J. Bathelt, Danae Mitsea, Hilde M. Geurts· bioRxiv· 0 citations
These findings provide a cell-type-resolved and ancestry-aware atlas of genetically regulated expression in the human prefrontal cortex and illustrate how single-nucleus transcriptomics can sharpen gene discovery and therapeutic target prioritization for complex brain disorders.
S. Venkatesh, Roman Kosoy, Zhen-Yi Wu et al.· Nature· 7 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.