Royal Netherlands

Visual deprivation in adulthood engages presynaptic plasticity of thalamocortical synapses

It is shown that robust and reversible plasticity can be induced in adult mice by prolonged dark exposure (DE) and light reintroduction (LRx) and that robust plasticity is engaged at thalamocortical synapses in adults by visual deprivation, a non-invasive manipulation with therapeutic potential.

Selective vulnerability of intracortical projection neurons drives long-term cortical circuit rewiring after perinatal hypoxia

Cortical circuits are built at perinatal times and gradually refined in an activity-dependent manner during a so-called postnatal period of critical plasticity. Although lesions of the central nervous system (CNS) happening during this period typically recover better than those occurring later in life, they are often a...

Network integration of neocortical Cajal-Retzius neurons shapes early cortical dynamics and contributes to their transient nature

Investigation of the structural and functional integration of CRN into developing neocortical networks with immunohistochemistry, three-dimensional reconstruction of GABAergic inputs, extracellular electrophysiology and calcium imaging found that CRN receive dense dendritic GABAergic synaptic inputs at early postnatal...

Bassoon is required for adult mouse ocular dominance plasticity and experience-induced changes in synapsin phosphorylation in visual cortex

Lateralized Tenm4 expression biases visual performance and modulates axonal growth and pre-synapse size in retinal ganglion cells

It is shown that the synaptic adhesion molecule Teneurin-4 (Tenm4) is expressed by RGCs and their postsynaptic tectal cell targets in a left-right side-specific manner in zebrafish, demonstrating that tenm4 plays an important role in sensorimotor circuit assembly, extending to neural activities and visual acuity.

in the

Exposure to 2 weeks of isolation and social defeat stress failed to alter the numbers of BrdU+, or DCX+ cells in the hippocampus or amygdala when evaluated 2 weeks after psychosocial stress, indicating that the current stress paradigm has no long-term consequences on neurogenesis in this primate.