2026· Current Topics in Developmental Biology· Vol 170, pp.
325-344
· 0 citations
Medicine
TL;DR
This chapter summarizes the broader landscape of omics profiling while focusing on how spatial transcriptomics and proteomics are uncovering the anatomical locations of erythropoiesis within the hematopoietic organs.
In insight into HSC aging, Pbx1 is identified as a key regulator of these age-related transcriptional and differentiation changes and may inform approaches to modulate age-associated HSC dysfunction.
This study provides a high-resolution transcriptional atlas of canine hematopoiesis and highlights conserved regulatory programs between dogs and humans, offering a reference for future studies of hematologic disease and cross-species comparisons.
Dylan T. Ammons, Christopher Contursi, McKenzie Olsen et al.· Scientific Reports· 2 citations
A panoramic landscape of the human hematopoietic system is established and its lifelong behaviors are elaborated, in which a steady-state reference enabled the delineation of pathological hallmarks across hematological malignancies.
Xiao-Wei Xie, Lian-Shuo Li, Fang Hong et al.· Protein & Cell· 0 citations
Comparisons with vertebrate hematopoiesis are drawn, identifying conserved regulatory logic in progenitor emergence, niche-mediated stem cell maintenance, and binary fate decisions, while noting species-specific differences that reflect the distinct complexity of each system.
Fermín Evangelisti, Pablo Wappner· Developmental Biology· 0 citations
The biological complexity of plants arises from highly coordinated cellular activities. We propose that a "cellular spatiotemporal dogma" governs the zygote's programmed development into a complete plant and its adaptation to various environmental stresses, representing the set of principles describing how gene express...
In utero lentiviral transduction is established as an efficient approach to resolve clonal lineages and address gene functions in defined gut cell types and reveals fundamental principles of multi-lineage organogenesis and provides a framework to dissect the contribution of developmental programs to visceral dysfunctio...
Zi-Wei Liu, Krishnanand Padmanabhan, Jing-Yan He et al.· bioRxiv· 0 citations
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