Early-life GABA-A receptor blockade with bicuculline attenuates anxiety-like behaviors and cognitive deficits induced by 24-hr sleep deprivation in adult male rats
Early postnatal transient blockade of GABA-A receptors was associated with decreased vulnerability to cognitive deficits, anxiety-like behaviors, and oxidative stress induced by acute sleep deprivation in adulthood, which reveals a novel developmental role of early GABAergic signaling in defense against sleep loss-induced neuropsychiatric and cognitive deficits.
Although TRIM59 has been reported to exert neuroprotective effects against brain injury, its role and underlying mechanisms in sleep disturbances remain unclear. This study aimed to elucidate the effect of Tripartite Motif Containing 59 (TRIM59) on sleep disorders and the associated hippocampal damage and cognitive dys...
Yang Zhang, Lin Li, Yilingrui Wang et al.· Neuropeptides· 0 citations
During adolescence, the brain is particularly vulnerable to sleep disruption, which may lead to long‑term memory deficits and emotional dysregulation. This study investigated the impact of REM sleep deprivation (REM‑SD), applied specifically during the acquisition phase of learning, on spatial memory, anxiety‑like beha...
Özge Selin Çevik, Yusuf Göktürk, Ümmühan Adam et al.· Acta Neurobiologiae Experime...· 0 citations
Disruption of cerebral cortical interneuron maturation has been implicated in the pathophysiology of schizophrenia, and NMDA receptor antagonists are widely used to model psychosis-relevant behavioral phenotypes in rodents. Dopamine D2 receptors (D2Rs) are expressed on cortical GABAergic interneurons derived from the m...
Y. Thabet, Samantha E. Neville, Aisha O. Shafau et al.· Discover Neuroscience· 0 citations
Sleep deprivation impairs cognitive function by disrupting hippocampal signaling pathways essential for memory formation. High-intensity interval training (HIIT) and lactate, a metabolic byproduct of exercise, have demonstrated potential benefits for brain plasticity, but their protective roles during sleep deprivation...
A. Movahed, H. Marefati, S. Aminizadeh et al.· Neuroscience Applied· 0 citations
The mPFC is a critical hub for CIH-induced cognitive impairment, and its targeted inhibition can restore cognitive and synaptic function, however, sleep architecture disruptions are governed by distinct mechanisms, indicating a dissociation between CIH-mediated cognitive and sleep pathologies.
Guo Pei, Xin-Yue Li, Yuan-Yuan Wang et al.· Journal of Neuroscience· 0 citations
BACKGROUND
Repeated propofol exposure during neurodevelopment induces long-term cognitive deficits in rats, potentially through dysregulated hippocampal neuronal autophagy and inhibition of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/mechanistic target of rapamycin (mTOR) pathway. Esketamine has bee...
Yang Wang, Yin Li, Zhe Chen et al.· Journal of Integrative Neuro...· 0 citations
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