TL;DR
It is proposed that surface stresses lead to a conserved cell wall remodeling response that is mainly governed by Mkc1, and is characterized by chitin reinforcement of the wall and the expression of remedial wall remodeling enzymes.
The results show that although hydrogen peroxide and paraquat induce msrA/B expression, the ΔmsrA/B strain was not susceptible to either oxidant, whereas the ΔclpX strain was sensitive to both.
A phenotypic pattern of medium- and epithelial cell type-specific cytotoxicity displayed by a C. albicans protein kinase mutant suggests that Crk1 regulates processes linked to carbon and amino acid metabolism that are relevant to interactions with intestinal epithelial cells.
Findings, which suggest a mechanism that transiently halts cell separation when cell wall integrity is compromised, highlight a link between cell wall homeostasis and the regulation of cell division in yeast.
MKK2 mediates the phosphorylation of the Mkc1 MAPK in response to cell wall assembly interfering agents such as zymolyase or tunicamycin and also to oxidative stress and it is shown here that Mkk2 mediates the phosphorylation of the Mkc1 MAPK under different stress conditions.
A physical interaction is identified between AaSlt2 and Swi6/RlmA, suggesting that these components are critical for cell wall synthesis, which advances the understanding of pathogenic mechanisms of A. alternata and proposes potential strategies for controlling postharvest diseases.
It is proposed that metabolic pathway competition for this shared intermediate between NADPH production and cell wall glucan biosynthesis underlies the cell wall weakness of TRR1-depleted cells, and decreased activity of a key UDP-glucose biosynthetic enzyme supports this mechanism.
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