TL;DR
It is proposed that M. lignano represents a novel powerful model for molecular studies of aging attenuation, and the identified aging gene expression patterns provide a valuable resource for further exploration of anti-aging strategies.
It is shown that ubiquitous degradation of DAF-2 in male C. elegans increases median lifespan by more than 440%, one of the longest lifespan extensions by a single intervention to date.
The shared longevity genes identified in this work offer potential targets to promote healthy aging and decrease age-onset disease.
The present paper summarizes previous theoretical studies that have suggested why broad regeneration in present only in some animals. It is speculated that the evolution of regenerative versus non-regenerative species is linked to specific environments where genes involved in regeneration can or cannot be expressed. Wh...
Organismal aging is not inevitable in multicellular animals, as early-branching metazoan lineages, such as cnidarians, display negligible senescence under defined conditions, despite conserved cellular pathways. Contrasting longevity phenotypes in Hydra species reveal distinct regulatory mechanisms underlying aging. A...
This study presents a comprehensive genetic characterization of DJ694, a viable GAL4 enhancer-trap allele of the age-regulated gene EDTP. EDTP transcript levels are reduced in DJ694, and homozygous flies exhibit reduced reproduction and shortened lifespan in both sexes. The fertility and longevity phenotypes are recess...
During mitotic growth, Saccharomyces cerevisiae cells age by dividing asymmetrically, producing young daughter cells while retaining age-associated damage in the mother cell, which will eventually become senescent. Gametogenesis naturally and fully resets precursor cell lifespan, even for replicatively aged cells...
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