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Neuronal Cell-Specific sc-eQTL and Integrative eQTL-pQTL Mendelian Randomization Prioritize CKAP2 as a Candidate Gene for Major Depressive Disorder

Xuejiao Hou Yin Huang
Aug 2026 · Journal of Molecular Neuroscience · Vol 76 · 0 citations · 39 references
Medicine

TL;DR

An integrative transcriptomic and proteomic Mendelian randomization study incorporating expression quantitative trait loci (eQTL) and protein quantitative trait loci (pQTL) datasets to prioritize genes associated with MDD prioritize CKAP2 as a candidate gene with convergent but non-confirmatory genetic evidence for involvement in MDD.

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