TL;DR
An extensive insight is provided into the dual role of SpA as a virulence factor in S. aureus pathogenesis and its widespread application in biotechnology, including its vital role in affinity purification of polyclonal and monoclonal antibodies.
This review provides a comprehensive overview of the major applications of SpA, with an emphasis on techniques that progressed to commercially available tools/platforms, and its use as a fusion partner/tag for capturing recombinant proteins.
This study demonstrates ImbA as an unrecognised plasmid-encoded virulence factor in A. baumannii that drives immune evasion and hypervirulence by intercepting host immunoglobulins, highlighting ImbA as a non-antibiotic therapeutic target with potential against multidrug-resistant A. baumannii.
Understanding the complex network of molecular crosstalk between ESKAPE pathogen metabolites and NK cells is fundamental for developing novel immunotherapy strategies for drug-resistant infections, designing adjuvant drugs based on bacterial components as well as correcting immune disorders in critical conditions.
It is shown that immunization with PDHC confers robust protection against lethal S. aureus strains, including MRSA, even in previously exposed hosts, as well as protecting against diverse S. aureus strains in multiple murine models.
Findings suggest that PGK may function as a moonlighting protein, playing an essential role in the interaction of S. aureus with its host through plasminogen binding.
A novel function of Ecb is revealed, the activation of basophils to produce IL-4 in an IgE-independent manner, and a dual Ecb contribution to immune evasion-by interfering with complement activation and skewing Th2 immunity-and a role in the development of allergic inflammation-by inducing IL-4 production is suggested.
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